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TA：佩雷拉靠清晰的战术、处理问题球员和在酒吧会见球迷拯救狼队_我的网站

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    Medicine File photo: VCG
China has granted marketing approval of its first drug for the prevention of acute mountain sickness, filling the long-standing gap in the domestic market where no such medications had been available, Science and Technology Daily reported on Tuesday.
The National Medical Products Administration (NMPA) has approved the marketing of acetazolamide sustained-release capsules, the report said. As the first specialized drug in China indicated for preventing of acute mountain sickness, its approval marks the end of the country's lack of dedicated preventive treatment for altitude illness. 
By inhibiting the activity of carbonic anhydrase, acetazolamide promotes the renal excretion of bicarbonate, corrects respiratory alkalosis caused by hypoxia at high altitudes, thereby regulating acid-base balance, optimizing respiratory status, elevating blood oxygen levels, and reducing the risk of onset at the source. 
In contrast to health products that only provide auxiliary regulatory effects, this medication has been validated through stringent clinical trials and stands as a specialized drug approved by the NMPA with a clear indication for prevention, said the report.
Led by principal investigator is Luobu Gesang, a deputy dean of the People's Hospital of Xizang Autonomous Region, the clinical trial was designed by his team and has yielded critical evidence to inform prevention strategies for altitude sickness that are specifically adapted to Chinese and Asian populations. 
"Previously, although acetazolamide had already been used internationally for the prevention of acute mountain sickness, China had long lacked an NMPA-approved acetazolamide formulation supported by rigorous clinical trials. Furthermore, the existing international formulations were short-acting tablets requiring multiple daily doses, and no drugs with the relevant indication were available on the domestic market for an extended period," said Luobu Gesang.
The sustained-release capsule approved this time not only fills this critical gap but also optimizes the dosage form, providing more reliable and convenient medication protection for the physical health and life safety of people entering high-altitude areas, he added.
Clinical trials showed that, compared with the placebo group, the incidence of acute mountain sickness in the medication group was significantly reduced, with the incidence of moderate-to-severe acute mountain sickness decreasing by 14.6 percent, according to the report.
Related research has been published in the international flagship journal of high-altitude medicine, High Altitude Medicine & Biology.
Global Times
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自去年圣诞前夕被任命以来，佩雷拉带领狼队从倒数第二到保级成功，更是45年来首次在联赛中双杀曼联。TA的一篇报道《佩雷拉如何拯救狼队：战术明晰、处理问题球员以及在酒吧与球迷交流》指出了他成功的关键。

简化体系，明确职责

对佩雷拉而言，接受球队后发现狼队最大的问题在于缺乏信心，球队的心态极其脆弱。他解决这个问题的主要办法是让战术明晰，消除球员们对自己职责的任何疑虑。 从他的首次训练课开始，佩雷拉就简化了战术，勾勒出一个更直接的体系，并把球员放在他们感到舒适的位置上，不过马特-多尔蒂成功改踢三中卫体系中的右中卫位置是个例外。

狼队的工作人员说道：“佩雷拉并没有采用什么‘灵丹妙药’ 或单一的诀窍来扭转球队的状态，但一些小的改变，比如让球员们同时一起用餐，以及恢复主场比赛前在酒店住宿的安排，以一些细微的方式恢复了一些失去的纪律。

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工作人员表示，佩雷拉在训练场最大的影响是他的计划更加明晰，并且凭借他丰富的经验树立了一定的权威，这妙地为俱乐部带来了一种纪律性。

同时，佩雷拉非常关注球员心态。他召开了一些全队会议，强调他对球员能力的信任，以及遵循他的计划将如何帮助他们重新发挥出实力。他还举行了一系列的一对一会议，在会议中，他挖掘个别球员心理上的任何缺陷，并试图加以修复。

铁腕整治问题球员

在1月6日主场0-3输给诺丁汉森林的比赛中，勒米纳作为替补表现不佳，之后佩雷拉将他排除在大名单之外。虽然他允许勒米纳继续和队友们一起训练，但他明确表示，不希望一个心思不在球队的有经验的球员留在这里。

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佩雷拉对克雷格-道森也采取了同样坚定的立场。这位34岁的后卫不在他的一线队计划中，所以，虽然没有纪律问题的迹象，但佩雷拉不希望一个心怀不满的资深球员留在球队里，可能影响团队的情绪，明确表示他在狼队的职业生涯实际上已经结束了。

四 | 虽然道森在今年夏天合同到期前仍将是球队的一名带薪员工，但自从2月初转会窗口关闭后不久，他就被免予参加训练了。

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工作人员认为，排除任何这样的潜在干扰因素，确保了球队能够保持专注，尽管转会窗口的开启确实给保级之路带来了唯一的真正波折。

从酒吧到未来

佩雷拉在职业生涯的大部分时间里都在等待进入英超联赛的机会，并且两次险些错过埃弗顿的主教练职位，但他已经成为了狼队球迷中的传奇英雄，这得益于他经常在当地酒吧与球迷们交流的习惯。预计狼队将在今年夏窗结束后，和他进行新合同的谈判。对于佩雷拉来说，巩固自己的地位还为时尚早。然而目前，他正沉浸在球迷的崇拜和尊重之中，他恢复了球队的权威和战术明晰度，拯救了一个原本即将失控的赛季。

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Published on:15:15:09